Dihydroberberine (GlucoSober®)
Dihydroberberine (DHB) is an advanced, bioavailable form of berberine, a natural alkaloid known for its metabolic, cardiovascular, and glucose-regulating benefits. Compared to traditional berberine, DHB is more absorbable and potent, making it a superior choice for supporting blood sugar control, insulin sensitivity, weight management, and cardiovascular health.
What is Dihydroberberine?
Dihydroberberine is a hydrogenated derivative of berberine, created through a natural gut microbial conversion process that enhances its bioavailability and cellular uptake. Traditional berberine is poorly absorbed and often causes gastrointestinal discomfort. In contrast, DHB offers up to 5x greater absorption and is more effective at lower doses.
Once absorbed, DHB converts back into berberine in the bloodstream, ensuring maximum efficacy while minimizing digestive issues.
Health Benefits of Dihydroberberine
- Regulates Blood Sugar and Improves Insulin Sensitivity
DHB activates AMP-activated protein kinase (AMPK), a key enzyme that enhances glucose metabolism and insulin signaling. This makes it particularly effective for individuals with type 2 diabetes, metabolic syndrome, or insulin resistance. Research shows DHB significantly lowers fasting blood glucose levels, reduces HbA1c, and improves overall glycemic control. - Supports Cardiovascular Health
By improving lipid metabolism, DHB helps reduce LDL cholesterol, increase HDL cholesterol, and lower triglyceride levels. Its anti-inflammatory properties further support healthy blood vessels and reduce oxidative stress, promoting overall cardiovascular well-being. - Aids in Weight Management and Fat Metabolism
DHB enhances fat oxidation and energy expenditure by stimulating AMPK activation. This process encourages the body to burn fat for energy, reducing excess fat storage and supporting weight loss efforts. It may also help reduce cravings and stabilize appetite. - Enhances Gut Health and Microbiome Balance
Unlike regular berberine, which can disrupt gut flora, DHB supports beneficial gut bacteria while reducing the overgrowth of harmful microbes. This promotes better digestion, reduced bloating, and improved gut barrier integrity. - Reduces Inflammation and Oxidative Stress
DHB acts as a powerful antioxidant and anti-inflammatory compound, helping to combat cellular damage, reduce systemic inflammation, and support healthy aging. - Improves Mitochondrial Function and Energy Levels
By activating AMPK and promoting efficient energy production, DHB enhances mitochondrial function, increases ATP production, and helps fight fatigue. This can benefit athletic performance and overall metabolic health.
Scientific Support
- Enhanced Bioavailability: DHB is 5x more absorbable than berberine and avoids gastrointestinal side effects (Moon et al., 2021).
- Blood Sugar Regulation & Insulin Sensitivity: Improves glucose metabolism, lowers HbA1c, and enhances insulin response (Utami et al., 2023).
- Cardiovascular Health: Reduces LDL cholesterol, triglycerides, and inflammation (Cao et al., 2021).
- Weight Management & Fat Oxidation: Activates AMPK, promoting fat-burning and metabolic efficiency (Ilyas et al., 2020).
- Gut Health Benefits: Supports beneficial gut bacteria and maintains microbiome balance (Zhang et al., 2020).