Nicotinamide mononucleotide (NMN) (ReV-AGE™)
Nicotinamide Mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a critical molecule involved in cellular energy production, DNA repair, and longevity-related processes. NMN supplementation has gained attention for its potential to enhance mitochondrial function, support metabolism, and promote healthy aging.
What is NMN?
NMN is a naturally occurring nucleotide derived from niacin (vitamin B3). It serves as a direct precursor to NAD+, an essential coenzyme that declines with age. By replenishing NAD+ levels, NMN plays a key role in maintaining cellular energy, improving metabolic function, and supporting overall vitality.
Health Benefits of NMN
- Boosts NAD+ Levels for Cellular Energy
NAD+ is essential for mitochondrial energy production, and NMN supplementation helps restore declining NAD+ levels associated with aging, leading to improved cellular function and energy metabolism. - Supports Healthy Aging and Longevity
By enhancing NAD+ availability, NMN activates sirtuins, a group of longevity-related proteins that regulate gene expression, DNA repair, and stress resistance, helping to slow down age-related decline. - Enhances Brain Function and Cognitive Health
NMN may support neuroprotection and cognitive function by improving mitochondrial efficiency in brain cells and reducing oxidative stress. It has been studied for its potential in protecting against neurodegenerative diseases such as Alzheimer’s. - Improves Metabolic Function and Insulin Sensitivity
NMN has been shown to enhance glucose metabolism and insulin sensitivity, making it a promising compound for individuals with metabolic disorders such as type 2 diabetes. - Supports Cardiovascular Health
By improving vascular function and blood flow, NMN helps maintain healthy heart function and circulation, reducing the risk of age-related cardiovascular diseases. - Promotes DNA Repair and Cellular Resilience
NAD+ plays a key role in DNA repair mechanisms, helping to protect cells from damage due to environmental stress, oxidative damage, and aging-related mutations.
Scientific Support
- NAD+ Restoration & Longevity: NMN supplementation increases NAD+ levels and activates sirtuins, promoting lifespan extension (Shade et al., 2020).
- Cognitive Health & Neuroprotection: Enhances mitochondrial function in the brain and protects against neurodegeneration (Ramanathan et al., 2022).
- Metabolic Benefits & Insulin Sensitivity: Improves glucose metabolism and insulin function in aging models (Yoshino et al., 2021).
- Cardiovascular Support: Enhances blood vessel function and reduces age-related vascular decline (Nadeeshani et al., 2022).
- DNA Repair & Cellular Health: Supports DNA repair mechanisms and cellular stress resilience (Rahman et al., 2024).