Fisetin (DR.FIS=TIN™)

Fisetin is a powerful flavonoid with antioxidant, anti-inflammatory, neuroprotective, and senolytic properties. Naturally found in strawberries, apples, onions, and persimmons, this bioactive compound is recognized for its ability to promote longevity, support cognitive function, and protect against age-related diseases.

What is Fisetin?

Fisetin is a polyphenol and flavonol belonging to the flavonoid family. It has gained significant attention for its potent antioxidant activity and its role as a senolytic compound, meaning it helps remove senescent (damaged, aging) cells that contribute to inflammation and aging-related diseases.

Its ability to cross the blood-brain barrier makes it particularly beneficial for brain health, neuroprotection, and cognitive longevity. Additionally, fisetin supports cardiovascular health, enhances cellular resilience, and modulates immune function.

Health Benefits of Fisetin

1. Powerful Antioxidant and Cellular Protection
   Fisetin is a potent free radical scavenger that reduces oxidative stress and protects cells from damage. It enhances glutathione levels, the body’s master antioxidant, helping to maintain cellular health and longevity.
2. Supports Brain Health and Cognitive Function
   Fisetin has neuroprotective properties that help reduce oxidative stress in the brain, enhance memory, and support learning ability. Studies suggest it may reduce the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s by preventing beta-amyloid accumulation and reducing brain inflammation.
3. Senolytic Effects: Removes Damaged Cells and Promotes Longevity
   One of fisetin’s most remarkable benefits is its ability to eliminate senescent cells, which accumulate with age and drive inflammation-related diseases. By removing these harmful cells, fisetin may slow down aging, improve tissue function, and extend lifespan.
4. Anti-Inflammatory Benefits for Overall Health
   Fisetin reduces chronic inflammation by inhibiting pro-inflammatory pathways such as NF-κB and COX-2, which are involved in conditions like arthritis, metabolic disorders, and autoimmune diseases.
5. Supports Cardiovascular Health
   Fisetin helps lower blood pressure, reduce arterial stiffness, and improve circulation by protecting endothelial cells and enhancing nitric oxide production. These effects contribute to reduced cardiovascular disease risk and improved heart health.
6. Enhances Immune Function and Reduces Inflammation
   By modulating immune cell activity and reducing excessive inflammation, fisetin may help protect against chronic diseases, infections, and immune system decline with age.
7. Potential Cancer-Preventive Properties
   Preliminary research suggests fisetin has anti-cancer effects by inhibiting tumor growth, inducing apoptosis (cell death) in cancer cells, and preventing metastasis. These properties make it a promising compound in cancer prevention strategies.

Scientific Support

1. Neuroprotection & Cognitive Health: Enhances memory and protects against neurodegeneration (Tang et al., 2023).
2. Senolytic & Longevity Effects: Removes senescent cells and extends lifespan in animal studies (Yousefzadeh et al., 2018).
3. Anti-Inflammatory & Immune Support: Modulates inflammation and improves immune function (Malogoda et al., 2023).
4. Cardiovascular Health: Protects endothelial cells and improves circulation (Mahoney et al., 2023).
5. Cellular Antioxidant Protection: Increases glutathione and reduces oxidative stress (Hassan et al., 2022).
6. Cancer Prevention: Induces apoptosis in cancer cells and inhibits tumor growth (Zhou et al., 2023).

References

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC10669030/
2. https://pubmed.ncbi.nlm.nih.gov/30279143/
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC8052411/
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC10928570/
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC9589363/
6. https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-023-01271-8