Cardiometabolic Health, Cognitive Health

Pyrroloquinoline quinone (PQQ) (BioPQQ™)

Pyrroloquinoline quinone (PQQ) (BioPQQ™) from Japan, is the highest grade powerful antioxidant and essential cofactor that supports mitochondrial function, brain health, cardiovascular wellness, and cellular energy production. Naturally found in certain foods and synthesized by bacteria, PQQ plays a crucial role in reducing oxidative stress, promoting neuroprotection, and enhancing metabolic efficiency.

What is Pyrroloquinoline Quinone (PQQ)?

PQQ is a redox cofactor involved in cellular energy metabolism and mitochondrial biogenesis. It is structurally similar to B vitamins and functions as a potent antioxidant, protecting cells from oxidative damage. PQQ is not synthesized by the human body, making dietary intake or supplementation essential for optimal health.

Health Benefits of PQQ

  1. Enhances Mitochondrial Function and Energy Production
    PQQ stimulates mitochondrial biogenesis, increasing the number and efficiency of mitochondria, the energy powerhouses of cells. This leads to improved cellular energy levels, reduced fatigue, and enhanced physical endurance.
  2. Supports Brain Health and Cognitive Function
    PQQ has neuroprotective effects, promoting memory retention, focus, and overall brain function. It helps combat neurodegenerative disorders by reducing oxidative damage in brain cells.
  3. Reduces Oxidative Stress and Inflammation
    As a potent antioxidant, PQQ neutralizes free radicals, reducing inflammation and protecting against cellular aging, DNA damage, and chronic diseases.
  4. Promotes Cardiovascular Health
    PQQ improves circulatory function and cardiovascular health by reducing LDL oxidation, lowering blood pressure, and enhancing endothelial function, thereby supporting heart health and blood flow.
  5. Enhances Sleep Quality and Reduces Fatigue
    Studies suggest that PQQ supplementation can improve sleep quality, reduce stress, and enhance overall energy levels, making it beneficial for those with chronic fatigue syndrome.

Scientific Support

  1. Mitochondrial Biogenesis & Energy Production: PQQ promotes new mitochondria formation and enhances energy metabolism (Chowanadisai et al., 2009).
  2. Cognitive Function & Neuroprotection: Improves memory, focus, and protects against neurodegeneration (Canovai et al., 2024).
  3. Antioxidant & Anti-Inflammatory Effects: Reduces oxidative stress and supports cellular longevity (Charrier et al., 2024).
  4. Cardiovascular Health: Lowers LDL oxidation and improves vascular function (Charrier et al., 2024).
  5. Sleep & Fatigue Reduction: Enhances sleep quality and reduces stress-related fatigue (Yan et al., 2024).

References

  1. https://pmc.ncbi.nlm.nih.gov/articles/PMC2804159/
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC11246121/
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC11429417/
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC11429417/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC11541945/