N-Acetyl-L-Cysteine (NAC)
N-Acetyl-L-Cysteine (NAC) is a powerful antioxidant and precursor to glutathione, the body’s master antioxidant. It plays a crucial role in detoxification, respiratory health, liver protection, and brain function. NAC is widely used for reducing oxidative stress, supporting immune function, and promoting overall cellular health.
What is N-Acetyl-L-Cysteine (NAC)?
NAC is a stable, bioavailable form of L-cysteine, an amino acid essential for producing glutathione. It is commonly used in nutritional supplements and medical treatments to protect against oxidative damage, inflammation, and toxin buildup. NAC has been studied extensively for its lung-clearing properties, liver detoxification benefits, and neuroprotective effects.
Health Benefits of NAC
- Boosts Glutathione Production and Reduces Oxidative Stress
NAC is a direct precursor to glutathione, which helps neutralize free radicals, reduce oxidative stress, and prevent cellular damage. This is particularly beneficial for liver health, immune support, and aging. - Supports Liver Detoxification
NAC is a well-established treatment for acetaminophen (paracetamol) overdose, as it protects liver cells from toxic damage. It also enhances liver function in individuals with chronic liver disease or toxin exposure. - Promotes Respiratory Health
NAC has mucolytic properties, meaning it breaks down and thins mucus in the lungs, making it easier to clear. It is commonly used for chronic respiratory conditions like chronic obstructive pulmonary disease (COPD), bronchitis, and asthma. - Supports Brain Function and Mental Health
NAC has neuroprotective effects, helping to combat oxidative damage and inflammation in the brain. It has been studied for its potential role in reducing symptoms of depression, anxiety, schizophrenia, and obsessive-compulsive disorder (OCD). - Enhances Immune Function
By reducing oxidative stress and replenishing glutathione levels, NAC supports immune defense against infections and chronic inflammation. Some studies suggest it may help reduce the severity of viral infections. - Aids in Cardiovascular Health
NAC may help lower homocysteine levels, a risk factor for cardiovascular disease, and improve vascular function by reducing oxidative damage to blood vessels.
Scientific Support
- Glutathione & Antioxidant Support: Enhances glutathione levels, reducing oxidative stress and cellular damage (Kerksick et al., 2005).
- Liver Detoxification: Protects against drug-induced liver injury and supports liver function (Ntamo et al., 2021).
- Respiratory Health: Improves mucus clearance and lung function in COPD and bronchitis patients (Sadowska et al., 2006).
- Brain & Mental Health: Shows promise in treating psychiatric disorders like OCD, schizophrenia, and bipolar disorder (Bradlow et al., 2022).
- Immune Support: Helps modulate immune function and may assist in managing viral infections (De Flora et al., 1997).
- Cardiovascular Benefits: Reduces oxidative damage to blood vessels and supports heart health (Sun et al., 2025).